OpenEye Medical

Macro-Dosing

Macro-Dosing: Profound Transformation & Deep Healing

Unlock the Depths of Your Mind

Macro-dosing with ketamine offers a powerful, immersive experience designed for those seeking profound emotional breakthroughs, trauma healing, and deep self-exploration.

Unlike micro-dosing, which provides subtle cognitive shifts over time, macro-dosing takes you into an altered state of consciousness, allowing you to access and process emotions, memories, and subconscious patterns in ways that traditional therapy cannot.

Whether you’re struggling with PTSD, depression, anxiety, trauma, or seeking spiritual insight, macro-dosing creates the space for radical self-discovery and emotional release—helping you rewire the mind and reshape your relationship with past experiences.

What is Macro-Dosing?

A macro-dose refers to a higher, immersive dose of ketamine that induces a deeply altered state of consciousness, often described as:

🔹 A dreamlike, dissociative state where everyday thoughts fade.

🔹 A detached yet insightful perspective on emotions, memories, and identity.

🔹 A feeling of ego-dissolution—a temporary release from personal identity and trauma loops.

🔹 A safe, controlled psychedelic journey with potential for healing and breakthroughs.

Macro-dosing is often referred to as the “K-Hole” experience, where the mind temporarily disconnects from ordinary perception, allowing deep subconscious material to surface.

Macro-Doses Help With:

✅ Processing & releasing deep trauma.
✅ Gaining profound clarity & new perspectives on life.
✅ Breaking free from negative thought loops & conditioning.
✅ Strengthening neuroplasticity, helping to rewire the brain for long-term healing.
✅ Creating a sense of peace, connection, and emotional reset.

Unlike micro-dosing, macro-dosing is best done in a structured, intentional setting where you can fully surrender to the experience and reflect afterward.

The Macro-Dosing Experience – What It Feels Like

A macro-dose experience unfolds in stages, guiding you through deep introspection and emotional release:

1️⃣ Onset (15-30 min after ingestion)

2️⃣ Dissociation (30-60 min)

As the ketamine takes effect, you’ll feel a gradual shifting of awareness. Sensory perceptions may soften, and you might notice:

🔹 A sense of heaviness or floating, as if gravity is shifting.

🔹 A warm, soothing calmness washing over your body.

🔹 Thoughts slowing down and becoming more fluid.

🔹 A feeling of detachment from stress, anxiety, or daily concerns.

At this stage, it’s best to close your eyes, relax, and allow the experience to unfold naturally.

This is the peak of the macro-dose experience, where everyday thoughts fade, and you enter a dreamlike, dissociative state.

🔹 A detachment from your physical body—it may feel distant or weightless.

🔹 Time distortion—minutes may feel like hours, or time may cease to exist altogether.

🔹 The feeling of “watching yourself” from an outside perspective—a shift that helps process emotions without attachment.

🔹 Reduction in fear and emotional resistance—allowing suppressed memories or emotions to surface without distress.

🔹 Ego-dissolution—a temporary release from personal identity and self-referential thinking.

This phase disrupts the rigid mental loops that contribute to depression, trauma, and anxiety, allowing you to step outside of conditioned thought patterns and view your life from a new perspective.

3️⃣ Expanded Awareness (60-90 min)

4️⃣ Integration (90 min - 3 hrs)

As the dissociation deepens, powerful insights may emerge. This is where the true healing potential of macro-dosing happens.

🔹 Visions or symbolic imagery—your mind may present meaningful visuals related to your healing journey.

🔹 Emotional processing—you may recall past events with new understanding, releasing trauma in a safe, detached way.

🔹 Cosmic or spiritual experiences—some describe feelings of universal connection, deep peace, or profound oneness.

🔹 Rewiring of thought patterns—many experience a sudden realization of how to move past emotional blocks.

🔹 Moments of surrender and profound acceptance, leading to a deep sense of relief and renewal.

Not everyone has a visionary or mystical experience, but most people emerge with a deeper understanding of themselves and their emotions.

As the effects fade, you’ll return to a clear, grounded state—but often with a sense of peace, clarity, and emotional lightness that lingers long after the session.

🔹 A feeling of mental reset, as if the brain has been refreshed.

🔹 Lasting emotional relief—many feel like a weight has been lifted.

🔹 Increased openness and mental flexibility—making it easier to adopt new perspectives and behaviors.

🔹 A sense of gratitude, acceptance, and deeper self-compassion.

This afterglow effect can last for days or even weeks, making it an ideal window for self-reflection, journaling, or therapy.

The Science Behind Macro-Dosing – How It Works in the Brain

Blocks NMDA Receptors:

Temporarily disrupts rigid thought loops associated with depression, PTSD, and anxiety.

Boosts Neuroplasticity:

Encourages the brain to form new, healthier connections, helping to reshape thinking patterns.

Releases Stored Trauma:

Suppressed emotions and memories resurface in a safe, altered state, allowing deep processing.

Regulates the Default Mode Network (DMN):

The part of the brain responsible for self-criticism and rumination is quieted, allowing greater emotional freedom.

Step-by-Step Guide – How to Macro-Dose

1️⃣ Before the Session:

  • Choose a comfortable, quiet space where you won’t be disturbed.
  • Set an intention—what do you want to explore or heal?
  • Have a journal nearby for post-session reflection.

2️⃣ During the Session

  • Wear an eye mask and listen to calming music to deepen the experience.
  • If difficult emotions arise, breathe and allow them to flow without resistance.
  • Let go of control—trust the process.

3️⃣ Lie Down & Surrender

  • Let Go of Expectations – Don’t try to analyze what’s happening—trust the process and observe.
  • Breathe Through Intensity – If emotions or visuals become overwhelming, slow, deep breathing keeps you grounded.
  • Don’t Fight Dissociation – If you feel yourself detaching from your body or identity, let it happen—this is where deep insights emerge.
  • Treat It Like a Dream – Instead of trying to control the experience, observe and experience it as you would in a lucid dream.
  • Let the Mind Expand – Thoughts may become abstract, symbolic, or nonlinear—embrace the journey instead of resisting it.

The key to a powerful and healing macro-dose session is surrender—the more you trust and allow, the deeper the transformation.

4️⃣ Grounding & Reorienting

  • Move Slowly & Mindfully – Avoid jumping back into intense activities. Take your time.
  • Drink Water or Herbal Tea – Hydration helps reconnect with the physical body.
  • Stretch or Do Gentle Movement – Light stretching or walking restores body awareness.
  • Engage Your Senses – Feel the texture of a blanket, listen to soft music, or light a candle to anchor yourself in the present moment.
  • Spend Time in Nature – If possible, step outside, feel the air, and ground your energy through contact with the earth.
  • Rest or Nap if Needed – Your brain has undergone intense work; allow it time to recalibrate.

5️⃣ Reflect & Integrate

  • Write it down – Journaling helps solidify insights and track progress.
  • Talk it out – Verbalizing the experience deepens understanding.
  • Move your body – Emotions are stored physically; movement releases them.
  • Express creatively – Art, music, and creativity give form to the ineffable.
  • Take small steps – Turning insights into real-life actions ensures lasting change.
  • Give it timeIntegration happens gradually—trust the process.

The Life You Deserve Is Waiting—Take the First Step Now

You don’t have to stay stuck in the past, trapped by pain, or waiting for change. Relief, clarity, and transformation are within reach. With our easy online application, a discreet and private treatment process, and direct access to our expert psychiatrists, starting your journey has never been simpler.

Whether you’re seeking subtle shifts or profound breakthroughs, our personalized ketamine therapy can help you reclaim your life.

Don’t wait another day—book your consultation now and step into the future you’ve been searching for.